I'd say right off the bat, use either @BrunoSupremo's River mod or archipelago mod. After playing the same landscapes over and over again, the change in scenery really helps refresh the game, and they (I presume) dive deep into the world gen code.
@Shinsaka's Better Stockpiles mod is a good look at item tags and UI Finagling.
To go with @MelOzone's interest with the lighting system, why not @8BitCrab's Forest Rune mod? Adds other light colors, for a new aesthetic.
P.S. Dunno if supposed to suggest mods now or when stream starts, so I'm doing it now.
Edit: OK. The "Hide Details" thing works in my preview but not when I actually post it. Weird.