Hey everyone, sorry you’re having this problem. “Saving” and “loading,” unfortunately, are not monolithic features. The hundreds (or thousands) of systems that are running when you save that must be written, in a proper order, to the save file, and on load, everything that was saved must be rehydrated. If we have a bug anywhere in any module’s save code, and the game happens to be in a bad state when you try to save, the save may fail. Any time we add or remove or tweak a feature, we run the risk of introducing more save/load bugs. Though we keep fixing these bugs, we can’t guarantee that they we’ve gotten all of them, or that we’ll never introduce more, until the game is feature complete.
For your particular versions of the save/load bug, how long have you been playing the game (in-game days) before it fails to save? Did you notice any bugs or red screens before the issue happened?
Whether or not autosave is on should have no bearing on the problem.