Hey @Blighter88, welcome to the forum
After this issue happens to you and you close the game, could you get the stonehearth.log file from C:\Program Files (x86)\Steam\steamapps\common\Stonehearth and upload it here? Maybe there’s some hint there that could help with the diagnose.
Does the game still run when the UI becomes unresponsive? Or does it look paused?
Which are your computer specs (CPU, RAM, OS, Graphic card)?