Having immediate lag spikes as soon as I create my settlement

Nope, sadly no more ideas beside that there could be something like an antivirus or other application interferring with the game, which might be completely wrong, it might be something else which is causing the spikes.

You can try searching for any of these applications and libraries on your computer, but they are mostly causing crashes so I doubt it’s one of them, besides your computer is pretty new so it shouldn’t have many things installed, I guess…

Maybe try running on compatibility mode (Windows 8 option)?